Mst2 and Lats Kinases Regulate Apoptotic Function of Yes Kinase-associated Protein (YAP)*
نویسندگان
چکیده
منابع مشابه
Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.
Ablation of the kinases Mst1 and Mst2, orthologs of the Drosophila antiproliferative kinase Hippo, from mouse intestinal epithelium caused marked expansion of an undifferentiated stem cell compartment and loss of secretory cells throughout the small and large intestine. Although median survival of mice lacking intestinal Mst1/Mst2 is 13 wk, adenomas of the distal colon are common by this age. D...
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Authors' Affiliations: 1 Department of Developmental, Molecular and Chemical Biology 8 Tufts University School of Medicine; Sackler School of Graduate Biomedical Sciences, Tufts 9 University; Department of Cancer Biology, Dana-Farber Cancer Institute; Department of 10 Biological Chemistry and Molecular Pharmacology; , 6 Department of Biochemistry, University 11 of Kashmir, Kashmir, India; 7 Dep...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.m804380200